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Inform individuals that: Tramadol Hydrochloride Prolonged-Release is for oral use only and will be swallowed entire. The capsule really should not be chewed, dissolved, crushed or split. Tramadol Hydrochloride Prolonged-Release might induce seizures and/or serotonin syndrome with concomitant use of serotonergic agents (together with SRIs, NRIs, and